Proteins of iron metabolism
نویسندگان
چکیده
منابع مشابه
Renal iron metabolism: transferrin iron delivery and the role of iron regulatory proteins.
I n mammalian cells, iron is required for the function of many prosthetic groups, including heme and iron-sulfur clusters. Mammals absorb dietary iron and heme across the apical mucosa of duodenal epithelial cells using a Fe transporter known as divalent metal transporter 1 (DMT-1; also known as solute carrier family 11 member 2, divalent cation transporter 1 (DCT1), and natural resistance asso...
متن کاملSteap proteins: implications for iron and copper metabolism.
Erythroid cells of the bone marrow, the most avid consumers of iron in the body, acquire ferric (Fe3+) iron exclusively via the transferrin cycling pathway. A long-standing fundamental molecular question of how ferric iron is handled in this pathway has been recently resolved by the identification of Steap3 (sixtransmembrane epithelial antigen of the prostate 3) as an endosomal ferrireductase n...
متن کاملThe role of iron regulatory proteins in the control of iron metabolism in mammals
The iron regulatory proteins (IRP1 and IRP2) are two cytoplasmic RNA-binding proteins involved in the mechanisms that control iron metabolism in mammalian cells. They modulate the expression of iron-related proteins at a post-transcriptional level by binding to specific iron regulatory elements (IREs) on their mRNAs. IRP-IRE interaction can block protein synthesis or stabilize the mRNA. At low ...
متن کاملCompartmentalization and regulation of iron metabolism proteins protect male germ cells from iron overload.
The universal importance of iron, its high toxicity, and complex chemistry present a challenge to biological systems in general and to protected compartments in particular. The high mitotic rate and avid mitochondriogenesis of developing male germ cells imply high iron requirements. Yet access to germ cells is tightly regulated by the blood-testis barrier that protects the meiotic and postmeiot...
متن کاملStudies on the metabolism of iron-containing proteins with radioactive carbon and iron.
Hemoglobin, of the iron-containing compounds, has received the most attention because of its quantitative importance and ease of isolation. In contrast, tracer studies with radioiron of ferritin, cytochrome c, and myoglobin, which are more difficult to isolate, have been less numerous. The uptake of Cl4 by these proteins has received almost no study. Of particular interest in relation to the pr...
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ژورنال
عنوان ژورنال: Nature
سال: 1979
ISSN: 0028-0836,1476-4687
DOI: 10.1038/279476b0